Assay Detail
Binding
CHEMBL758127
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Inhibition of [3H]DAMGO binding to Opioid receptor mu 1 from mouse brain membranes.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.25 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL101694 | — | — | 1 | 9.42 |
| CHEMBL105081 | — | — | 1 | 9.14 |
| CHEMBL610293 | — | — | 1 | 8.82 |
| CHEMBL104159 | — | — | 1 | 8.55 |
| CHEMBL399708 | SPIROINDANYLOXYMORPHONE | — | 1 | 7.85 |
| CHEMBL104179 | — | — | 1 | 7.75 |
| CHEMBL318598 | — | — | 1 | 7.55 |
| CHEMBL318361 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL101694 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL105081 | — | Ki | = | 0.72 | nM | 9.14 |
| CHEMBL610293 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL104159 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL399708 | SPIROINDANYLOXYMORPHONE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL104179 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL318598 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL318361 | — | Ki | = | 119.0 | nM | 6.92 |