Assay Detail
Binding
CHEMBL758257
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity using guinea pig brain membrane preparations, towards Opioid receptor kappa 1 using [3H]- U-69,593 as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.24 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58362 | — | — | 1 | 7.10 |
| CHEMBL61630 | — | — | 1 | 6.91 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 6.33 |
| CHEMBL299031 | — | — | 1 | 5.96 |
| CHEMBL60533 | CORYNANRHEIDINE | — | 1 | 5.59 |
| CHEMBL292521 | — | — | 1 | 5.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58362 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL61630 | — | Ki | = | 123.03 | nM | 6.91 |
| CHEMBL70 | MORPHINE | Ki | = | 467.74 | nM | 6.33 |
| CHEMBL299031 | — | Ki | = | 1096.48 | nM | 5.96 |
| CHEMBL60533 | CORYNANRHEIDINE | Ki | = | 2570.4 | nM | 5.59 |
| CHEMBL292521 | — | Ki | = | 2951.21 | nM | 5.53 |