Assay Detail
Binding
CHEMBL758270
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Inhibitory activity towards electrically induced contractions in guinea pig ileum expressing Opioid receptor mu 1
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structure-activity relationships of cyclic opioid peptide analogues containing a phenylalanine residue in the 3-position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.79 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65047 | — | — | 1 | 6.96 |
| CHEMBL63235 | — | — | 1 | 6.55 |
| CHEMBL68177 | — | — | 1 | 6.28 |
| CHEMBL303513 | — | — | 1 | 6.20 |
| CHEMBL303418 | — | — | 1 | 5.63 |
| CHEMBL304431 | — | — | 1 | 5.19 |
| CHEMBL64949 | — | — | 1 | 4.78 |
| CHEMBL66039 | — | — | 1 | 4.74 |
| CHEMBL63972 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65047 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL63235 | — | IC50 | = | 279.0 | nM | 6.55 |
| CHEMBL68177 | — | IC50 | = | 522.0 | nM | 6.28 |
| CHEMBL303513 | — | IC50 | = | 632.0 | nM | 6.20 |
| CHEMBL303418 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL304431 | — | IC50 | = | 6460.0 | nM | 5.19 |
| CHEMBL64949 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL66039 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL63972 | — | IC50 | > | 21000.0 | nM | - |