Assay Detail
Binding
CHEMBL758274
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Inhibitory potency against Opioid receptor mu 1 in longitudinal muscle preparation of guinea pig ileum
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Evidence of the preferential involvement of mu receptors in analgesia using enkephalins highly selective for peripheral mu or delta receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.02 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274204 | — | — | 1 | 8.14 |
| CHEMBL13894 | — | — | 1 | 7.66 |
| CHEMBL340032 | DADLE | — | 1 | 7.32 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 7.16 |
| CHEMBL280274 | — | — | 1 | 7.00 |
| CHEMBL14094 | — | — | 1 | 6.74 |
| CHEMBL13786 | — | — | 1 | 6.70 |
| CHEMBL14036 | — | — | 1 | 6.62 |
| CHEMBL14230 | — | — | 1 | 6.44 |
| CHEMBL14204 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274204 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL13894 | — | IC50 | = | 21.9 | nM | 7.66 |
| CHEMBL340032 | DADLE | IC50 | = | 47.8 | nM | 7.32 |
| CHEMBL70 | MORPHINE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL280274 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL14094 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL13786 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL14036 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL14230 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL14204 | — | IC50 | = | 380.0 | nM | 6.42 |