Assay Detail
Functional
CHEMBL758275
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electrically evoked contraction of guinea pig ileum (myenteric plexus:longitudinal muscle preparation) by antagonist action at mu 1 opioid receptors
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Investigation of the structural parameters involved in the mu and delta opioid receptor discrimination of linear enkephalin-related peptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.59 | 7.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38874 | DAMGO | — | 1 | 7.94 |
| CHEMBL2370601 | — | — | 1 | 7.67 |
| CHEMBL125060 | — | — | 1 | 7.19 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 7.16 |
| CHEMBL2370602 | — | — | 1 | 7.06 |
| CHEMBL125564 | — | — | 1 | 7.00 |
| CHEMBL2370600 | — | — | 1 | 6.96 |
| CHEMBL338773 | — | — | 1 | 6.81 |
| CHEMBL339020 | — | — | 1 | 6.70 |
| CHEMBL123631 | — | — | 1 | 6.67 |
| CHEMBL341480 | — | — | 1 | 6.65 |
| CHEMBL419414 | — | — | 1 | 6.62 |
| CHEMBL338307 | — | — | 1 | 6.59 |
| CHEMBL127711 | — | — | 1 | 6.58 |
| CHEMBL275050 | — | — | 1 | 6.49 |
| CHEMBL341500 | — | — | 1 | 6.42 |
| CHEMBL124283 | — | — | 1 | 6.39 |
| CHEMBL127378 | — | — | 1 | 6.34 |
| CHEMBL2370599 | — | — | 1 | 6.14 |
| CHEMBL339002 | — | — | 1 | 5.73 |
| CHEMBL31421 | — | — | 1 | 5.00 |
| CHEMBL333064 | — | — | 1 | 4.85 |
| CHEMBL14094 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38874 | DAMGO | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL2370601 | — | IC50 | = | 21.3 | nM | 7.67 |
| CHEMBL125060 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL70 | MORPHINE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2370602 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL125564 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL2370600 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL338773 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL339020 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL123631 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL341480 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL419414 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL338307 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL127711 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL275050 | — | IC50 | = | 323.0 | nM | 6.49 |
| CHEMBL341500 | — | IC50 | = | 379.0 | nM | 6.42 |
| CHEMBL124283 | — | IC50 | = | 406.0 | nM | 6.39 |
| CHEMBL127378 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL2370599 | — | IC50 | = | 718.0 | nM | 6.14 |
| CHEMBL339002 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL31421 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL333064 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL14094 | — | IC50 | >= | 50000.0 | nM | - |