Assay Detail
Functional
CHEMBL758490
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-HIV activity against multidrug resistant HIV JSL strain by inhibition of HIV p24 antigen expression in peripheral blood mononuclear cells(PBMC)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Reduction of peptide character of HIV protease inhibitors that exhibit nanomolar potency against multidrug resistant HIV-1 strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.71 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL299578 | — | — | 1 | 7.60 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.19 |
| CHEMBL49002 | — | — | 1 | 6.66 |
| CHEMBL50945 | — | — | 1 | 6.47 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 6.26 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL299578 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL49002 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL50945 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL114 | SAQUINAVIR | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL116 | AMPRENAVIR | IC50 | = | 800.0 | nM | 6.10 |