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Assay Detail

CHEMBL758560

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro concentration required to inhibit the HIV-1 LA1 replication on PBMCs cell (peripheral blood mononuclear cells)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type PBMCs
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

Are 5'-O-carbamate-2',3'-dideoxythiacytidine new anti-HIV and anti-HBV nucleoside drugs or prodrugs?
Anastasi C, Vlieghe P, Hantz O, Schorr O, Pannecouque C, Witvrouw M, De Clercq E, Clayette P, Dereuddre-Bosquet N, Dormont D, Gondois-Rey F, Hirsch I, Kraus JL.
Bioorg Med Chem Lett (2003) 13 : 2459 -2463
PubMed 12852943 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 12 6.03 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL81640 1 8.00
CHEMBL141 LAMIVUDINE 4.0 1 8.00
CHEMBL82186 1 7.00
CHEMBL311928 1 6.00
CHEMBL312478 1 5.30
CHEMBL311500 1 5.00
CHEMBL310302 1 5.00
CHEMBL79911 1 5.00
CHEMBL420590 1 5.00
CHEMBL81317 1 -
CHEMBL310110 1 -
CHEMBL83805 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL81640 EC50 = 10.0 nM 8.00
CHEMBL141 LAMIVUDINE EC50 = 10.0 nM 8.00
CHEMBL82186 EC50 = 100.0 nM 7.00
CHEMBL311928 EC50 = 1000.0 nM 6.00
CHEMBL312478 EC50 = 5000.0 nM 5.30
CHEMBL311500 EC50 = 10000.0 nM 5.00
CHEMBL310302 EC50 = 10000.0 nM 5.00
CHEMBL79911 EC50 = 10000.0 nM 5.00
CHEMBL420590 EC50 = 10000.0 nM 5.00
CHEMBL81317 EC50 > 10000.0 nM -
CHEMBL310110 EC50 > 10000.0 nM -
CHEMBL83805 EC50 > 10000.0 nM -