Assay Detail
Binding
CHEMBL758575
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Inhibition of [3H]DAGO binding to rat Opioid receptor mu 1
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Stereospecificity of amino acid side chains in deltorphin defines binding to opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.22 | 6.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282873 | — | — | 1 | 6.91 |
| CHEMBL21177 | — | — | 1 | 6.83 |
| CHEMBL279132 | — | — | 1 | 6.57 |
| CHEMBL281845 | — | — | 1 | 6.48 |
| CHEMBL277862 | — | — | 1 | 6.45 |
| CHEMBL435762 | — | — | 1 | 6.39 |
| CHEMBL20422 | — | — | 1 | 6.25 |
| CHEMBL283763 | — | — | 1 | 6.16 |
| CHEMBL278289 | — | — | 1 | 5.98 |
| CHEMBL296603 | DELTORPHINE II | — | 1 | 5.89 |
| CHEMBL21192 | — | — | 1 | 5.65 |
| CHEMBL280669 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282873 | — | Ki | = | 124.5 | nM | 6.91 |
| CHEMBL21177 | — | Ki | = | 146.2 | nM | 6.83 |
| CHEMBL279132 | — | Ki | = | 266.7 | nM | 6.57 |
| CHEMBL281845 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL277862 | — | Ki | = | 351.7 | nM | 6.45 |
| CHEMBL435762 | — | Ki | = | 407.1 | nM | 6.39 |
| CHEMBL20422 | — | Ki | = | 567.1 | nM | 6.25 |
| CHEMBL283763 | — | Ki | = | 690.6 | nM | 6.16 |
| CHEMBL278289 | — | Ki | = | 1047.0 | nM | 5.98 |
| CHEMBL296603 | DELTORPHINE II | Ki | = | 1280.0 | nM | 5.89 |
| CHEMBL21192 | — | Ki | = | 2253.0 | nM | 5.65 |
| CHEMBL280669 | — | Ki | = | 7410.0 | nM | 5.13 |