Assay Detail
Binding
CHEMBL758580
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity at opioid receptor mu 1 was determined in C6 rat glioma cells using [3H]DAMGO
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | C6 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of 14-alkoxymorphinans. 18. N-substituted 14-phenylpropyloxymorphinan-6-ones with unanticipated agonist properties: extending the scope of common structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 9.34 | 10.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL326684 | — | — | 1 | 10.64 |
| CHEMBL606985 | — | — | 1 | 10.05 |
| CHEMBL606925 | — | — | 1 | 9.70 |
| CHEMBL606986 | — | — | 1 | 9.70 |
| CHEMBL606924 | — | — | 1 | 9.60 |
| CHEMBL514774 | — | — | 1 | 9.47 |
| CHEMBL606987 | — | — | 1 | 8.96 |
| CHEMBL606923 | — | — | 1 | 8.72 |
| CHEMBL606876 | — | — | 1 | 8.42 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 8.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL326684 | — | Ki | = | 0.023 | nM | 10.64 |
| CHEMBL606985 | — | Ki | = | 0.09 | nM | 10.05 |
| CHEMBL606925 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL606986 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL606924 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL514774 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL606987 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL606923 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL606876 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL70 | MORPHINE | Ki | = | 6.55 | nM | 8.18 |