Assay Detail
Binding
CHEMBL758585
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro radioligand binding assay, for inhibition of [3H]DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 in rat brain membranes at highest concentration of 6300 nM tested
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Probes for narcotic receptor mediated phenomena. 26. Synthesis and biological evaluation of diarylmethylpiperazines and diarylmethylpiperidines as novel, nonpeptidic delta opioid receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.00 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL541349 | — | — | 1 | 5.00 |
| CHEMBL545335 | — | — | 1 | 5.00 |
| CHEMBL555570 | — | — | 1 | 5.00 |
| CHEMBL542267 | — | — | 1 | 5.00 |
| CHEMBL544638 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL541349 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL545335 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL555570 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL542267 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL544638 | — | Ki | = | 10000.0 | nM | 5.00 |