Assay Detail

CHEMBL758677

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Functional

Tested for Oxidosqualene-lanosterol cyclase inhibition in Trypanosoma cruzi

ChEMBL ↗

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Target

Lanosterol synthase (CHEMBL3593) ↗

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Primary target Lanosterol synthase

CHEMBL3593

Anchored from Assay target.

Protein identity Lanosterol synthase

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Trypanosoma cruzi
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Lanosterol synthase (CHEMBL3593) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Oxidosqualene cyclase inhibitors as antimicrobial agents.

Hinshaw JC, Suh DY, Garnier P, Buckner FS, Eastman RT, Matsuda SP, Joubert BM, Coppens I, Joiner KA, Merali S, Nash TE, Prestwich GD.
J Med Chem (2003) 46 : 4240 -4243
PubMed 13678402 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.40	6.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL25405	—	—	1	6.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL25405	—	IC50	=	400.0	nM	6.40