Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL758726

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro opioid receptor delta mediated mouse vas deferens (MVD) assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Tissue Vas deferens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Delta-type opioid receptor (CHEMBL3222)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Synthesis and structure-activity relationships of deltorphin analogues.
Salvadori S, Marastoni M, Balboni G, Borea PA, Morari M, Tomatis R.
J Med Chem (1991) 34 : 1656 -1661
PubMed 1851843 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 8.30 9.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL281140 1 9.85
CHEMBL29078 1 9.12
CHEMBL296749 1 8.99
CHEMBL32202 1 8.89
CHEMBL45308 1 8.89
CHEMBL297059 1 8.82
CHEMBL46540 1 8.80
CHEMBL296603 DELTORPHINE II 1 8.26
CHEMBL295076 1 8.12
CHEMBL297567 1 8.10
CHEMBL47156 1 8.05
CHEMBL278789 DERMORPHIN 1 7.71
CHEMBL294982 1 6.66
CHEMBL44172 1 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL281140 IC50 = 0.14 nM 9.85
CHEMBL29078 IC50 = 0.75 nM 9.12
CHEMBL296749 IC50 = 1.02 nM 8.99
CHEMBL32202 IC50 = 1.3 nM 8.89
CHEMBL45308 IC50 = 1.3 nM 8.89
CHEMBL297059 IC50 = 1.5 nM 8.82
CHEMBL46540 IC50 = 1.6 nM 8.80
CHEMBL296603 DELTORPHINE II IC50 = 5.55 nM 8.26
CHEMBL295076 IC50 = 7.5 nM 8.12
CHEMBL297567 IC50 = 8.0 nM 8.10
CHEMBL47156 IC50 = 9.0 nM 8.05
CHEMBL278789 DERMORPHIN IC50 = 19.3 nM 7.71
CHEMBL294982 IC50 = 220.0 nM 6.66
CHEMBL44172 IC50 = 1000.0 nM 6.00