Assay Detail
Functional
CHEMBL758925
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-HIV-1 activity against human peripheral blood mononuclear (PBM) cells infected with HIV-1 strain LAV
41
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus (CHEMBL613758) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus |
Publication
Asymmetric synthesis and biological evaluation of beta-L-(2R,5S)- and alpha-L-(2R,5R)-1,3-oxathiolane-pyrimidine and -purine nucleosides as potential anti-HIV agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 41 | 5.67 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL885 | EMTRICITABINE | 4.0 | 1 | 8.89 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 4 | 8.74 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.40 |
| CHEMBL58809 | — | — | 1 | 6.85 |
| CHEMBL292175 | — | — | 1 | 6.37 |
| CHEMBL293564 | — | — | 1 | 6.35 |
| CHEMBL278444 | — | — | 1 | 6.00 |
| CHEMBL57917 | — | — | 1 | 5.84 |
| CHEMBL60483 | — | — | 1 | 5.72 |
| CHEMBL59067 | — | — | 1 | 5.60 |
| CHEMBL263438 | — | — | 1 | 5.56 |
| CHEMBL292358 | — | — | 1 | 5.36 |
| CHEMBL293575 | — | — | 1 | 5.01 |
| CHEMBL57129 | — | — | 1 | 4.99 |
| CHEMBL300569 | — | — | 1 | 4.93 |
| CHEMBL58457 | — | — | 1 | 4.89 |
| CHEMBL57786 | — | — | 1 | 4.82 |
| CHEMBL59576 | — | — | 1 | 4.80 |
| CHEMBL58544 | — | — | 1 | 4.79 |
| CHEMBL301042 | — | — | 1 | 4.50 |
| CHEMBL60768 | — | — | 1 | 4.48 |
| CHEMBL294690 | — | — | 1 | 4.46 |
| CHEMBL294695 | — | — | 1 | 4.38 |
| CHEMBL58461 | — | — | 1 | 4.10 |
| CHEMBL418146 | — | — | 1 | 4.03 |
| CHEMBL61093 | — | — | 1 | - |
| CHEMBL60981 | — | — | 1 | - |
| CHEMBL300546 | — | — | 1 | - |
| CHEMBL301891 | — | — | 1 | - |
| CHEMBL300582 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL885 | EMTRICITABINE | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL58809 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL292175 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL293564 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL278444 | — | EC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL57917 | — | EC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL60483 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL59067 | — | EC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL263438 | — | EC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL292358 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL293575 | — | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL57129 | — | EC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL300569 | — | EC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL58457 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL57786 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL59576 | — | EC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL58544 | — | EC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL301042 | — | EC50 | = | 31800.0 | nM | 4.50 |
| CHEMBL60768 | — | EC50 | = | 32800.0 | nM | 4.48 |
| CHEMBL294690 | — | EC50 | = | 34300.0 | nM | 4.46 |
| CHEMBL294695 | — | EC50 | = | 42100.0 | nM | 4.38 |
| CHEMBL58461 | — | EC50 | = | 78900.0 | nM | 4.10 |
| CHEMBL418146 | — | EC50 | = | 92900.0 | nM | 4.03 |
| CHEMBL299930 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL291470 | — | EC50 | = | 121000.0 | nM | - |
| CHEMBL301886 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL60858 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL61181 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL294694 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL59553 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL301450 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL300582 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL301891 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL300546 | — | EC50 | = | 157000.0 | nM | - |
| CHEMBL60981 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL61093 | — | EC50 | > | 100000.0 | nM | - |