Assay Detail

CHEMBL758930

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Functional

Antiviral activity against HIV I strain (LAV) in human peripheral blood mononuclear (PBM) cells; Range is 0.009 - 0.04

ChEMBL ↗

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Target

ADMET (CHEMBL612558) ↗

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Primary target ADMET

CHEMBL612558

Anchored from Assay target.

Protein identity ADMET

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

ADMET (CHEMBL612558) ↗

Type

ADMET

Publication

Structure-activity relationships of pyrimidine nucleosides as antiviral agents for human immunodeficiency virus type 1 in peripheral blood mononuclear cells.

Chu CK, Schinazi RF, Ahn MK, Ullas GV, Gu ZP.
J Med Chem (1989) 32 : 612 -617
PubMed 2918508 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	8.05	8.05

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL991	STAVUDINE	4.0	1	8.05

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL991	STAVUDINE	EC50	=	9.0	nM	8.05