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Assay Detail

CHEMBL758936

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity was evaluated in mitogen-stimulated human peripheral blood mononuclear (PBM) cells infected with HIV-1 strain LAV
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

1,3-dioxolanylpurine nucleosides (2R,4R) and (2R,4S) with selective anti-HIV-1 activity in human lymphocytes.
Kim HO, Schinazi RF, Nampalli S, Shanmuganathan K, Cannon DL, Alves AJ, Jeong LS, Beach JW, Chu CK.
J Med Chem (1993) 36 : 30 -37
PubMed 8421287 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 13 5.60 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL417332 1 7.52
CHEMBL123983 1 6.52
CHEMBL58342 1 6.41
CHEMBL38860 1 6.30
CHEMBL339198 1 6.16
CHEMBL123644 1 5.60
CHEMBL121749 1 5.30
CHEMBL122399 1 5.21
CHEMBL123020 1 4.84
CHEMBL123419 1 4.60
CHEMBL333239 1 4.52
CHEMBL334139 1 4.24
CHEMBL123461 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL417332 EC50 = 30.0 nM 7.52
CHEMBL123983 EC50 = 300.0 nM 6.52
CHEMBL58342 EC50 = 390.0 nM 6.41
CHEMBL38860 EC50 = 500.0 nM 6.30
CHEMBL339198 EC50 = 700.0 nM 6.16
CHEMBL123644 EC50 = 2500.0 nM 5.60
CHEMBL121749 EC50 = 5000.0 nM 5.30
CHEMBL122399 EC50 = 6200.0 nM 5.21
CHEMBL123020 EC50 = 14300.0 nM 4.84
CHEMBL123419 EC50 = 25100.0 nM 4.60
CHEMBL333239 EC50 = 30300.0 nM 4.52
CHEMBL334139 EC50 = 58100.0 nM 4.24
CHEMBL123461 EC50 > 100000.0 nM -