Assay Detail
Functional
CHEMBL758938
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro antiviral activity in Phytohemagglutininin stimulated human PBM cells infected with HIV-1 (strain LAV-1)
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | PBM |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and quantitative structure-activity relationship analysis of 2-(aryl or heteroaryl)quinolin-4-amines, a new class of anti-HIV-1 agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 38 | 4.92 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298050 | — | — | 1 | 6.24 |
| CHEMBL48063 | — | — | 1 | 6.04 |
| CHEMBL433267 | — | — | 1 | 6.00 |
| CHEMBL51136 | — | — | 1 | 6.00 |
| CHEMBL49292 | — | — | 1 | 5.87 |
| CHEMBL301711 | — | — | 1 | 5.82 |
| CHEMBL301352 | — | — | 1 | 5.55 |
| CHEMBL47004 | — | — | 1 | 5.39 |
| CHEMBL300650 | — | — | 1 | 5.37 |
| CHEMBL21808 | — | — | 1 | 5.35 |
| CHEMBL45941 | — | — | 1 | 5.31 |
| CHEMBL49678 | — | — | 1 | 5.26 |
| CHEMBL296625 | — | — | 1 | 5.07 |
| CHEMBL49256 | — | — | 1 | 5.04 |
| CHEMBL49055 | — | — | 1 | 5.00 |
| CHEMBL46258 | — | — | 1 | 4.98 |
| CHEMBL49109 | — | — | 1 | 4.88 |
| CHEMBL300659 | — | — | 1 | 4.88 |
| CHEMBL48514 | — | — | 1 | 4.88 |
| CHEMBL47232 | — | — | 1 | 4.80 |
| CHEMBL301925 | — | — | 1 | 4.78 |
| CHEMBL45721 | — | — | 1 | 4.73 |
| CHEMBL49830 | — | — | 1 | 4.70 |
| CHEMBL51731 | — | — | 1 | 4.62 |
| CHEMBL50608 | — | — | 1 | 4.59 |
| CHEMBL48187 | — | — | 1 | 4.58 |
| CHEMBL295412 | — | — | 1 | 4.49 |
| CHEMBL297699 | — | — | 1 | 4.47 |
| CHEMBL49300 | — | — | 1 | 4.46 |
| CHEMBL298676 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298050 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL48063 | — | EC50 | = | 910.0 | nM | 6.04 |
| CHEMBL51136 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL433267 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL49292 | — | EC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL301711 | — | EC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL301352 | — | EC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL47004 | — | EC50 | = | 4080.0 | nM | 5.39 |
| CHEMBL300650 | — | EC50 | = | 4240.0 | nM | 5.37 |
| CHEMBL21808 | — | EC50 | = | 4470.0 | nM | 5.35 |
| CHEMBL45941 | — | EC50 | = | 4860.0 | nM | 5.31 |
| CHEMBL49678 | — | EC50 | = | 5510.0 | nM | 5.26 |
| CHEMBL296625 | — | EC50 | = | 8560.0 | nM | 5.07 |
| CHEMBL49256 | — | EC50 | = | 9070.0 | nM | 5.04 |
| CHEMBL49055 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL46258 | — | EC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL49109 | — | EC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL300659 | — | EC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL48514 | — | EC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL47232 | — | EC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL301925 | — | EC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL45721 | — | EC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL49830 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL51731 | — | EC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL50608 | — | EC50 | = | 25700.0 | nM | 4.59 |
| CHEMBL48187 | — | EC50 | = | 26400.0 | nM | 4.58 |
| CHEMBL295412 | — | EC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL297699 | — | EC50 | = | 33700.0 | nM | 4.47 |
| CHEMBL298676 | — | EC50 | = | 34300.0 | nM | 4.46 |
| CHEMBL49300 | — | EC50 | = | 34800.0 | nM | 4.46 |
| CHEMBL301554 | — | EC50 | = | 36900.0 | nM | 4.43 |
| CHEMBL46206 | — | EC50 | = | 44200.0 | nM | 4.36 |
| CHEMBL48171 | — | EC50 | = | 50600.0 | nM | 4.30 |
| CHEMBL48064 | — | EC50 | = | 68200.0 | nM | 4.17 |
| CHEMBL442959 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL297128 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL430766 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL301832 | — | EC50 | = | 100000.0 | nM | 4.00 |