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Assay Detail

CHEMBL758940

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Effective concentration against HIV-1 in peripheral blood mononuclear cells (PBM).
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

Asymmetric synthesis of 1,3-dioxolane-pyrimidine nucleosides and their anti-HIV activity.
Kim HO, Ahn SK, Alves AJ, Beach JW, Jeong LS, Choi BG, Van Roey P, Schinazi RF, Chu CK.
J Med Chem (1992) 35 : 1987 -1995
PubMed 1597854 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 12 5.76 7.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL58342 1 7.05
CHEMBL300793 1 6.80
CHEMBL300589 1 5.62
CHEMBL60381 1 5.17
CHEMBL61323 1 4.16
CHEMBL300554 1 -
CHEMBL60438 1 -
CHEMBL292278 1 -
CHEMBL64278 1 -
CHEMBL64326 1 -
CHEMBL61386 1 -
CHEMBL64774 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL58342 EC50 = 90.0 nM 7.05
CHEMBL300793 EC50 = 160.0 nM 6.80
CHEMBL300589 EC50 = 2400.0 nM 5.62
CHEMBL60381 EC50 = 6800.0 nM 5.17
CHEMBL61323 EC50 = 69600.0 nM 4.16
CHEMBL300554 EC50 > 100000.0 nM -
CHEMBL60438 EC50 > 100000.0 nM -
CHEMBL292278 EC50 > 100000.0 nM -
CHEMBL64278 EC50 > 100000.0 nM -
CHEMBL64326 EC50 > 100000.0 nM -
CHEMBL61386 EC50 > 100000.0 nM -
CHEMBL64774 EC50 > 100000.0 nM -