Assay Detail
Functional
CHEMBL758941
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Effective concentration against HIV-1 in peripheral blood mononuclear cells(PBM).
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Asymmetric synthesis of 1,3-dioxolane-pyrimidine nucleosides and their anti-HIV activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.50 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.05 |
| CHEMBL304445 | — | — | 1 | 6.41 |
| CHEMBL303553 | — | — | 1 | 5.03 |
| CHEMBL60834 | — | — | 1 | - |
| CHEMBL57960 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL304445 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL303553 | — | EC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL60834 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL57960 | — | EC50 | > | 100000.0 | nM | - |