Assay Detail
Binding
CHEMBL759069
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Inhibition of protein kinase C alpha
10
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent and selective PKC inhibitory 5-membered ring analogs of balanol with replacement of the carboxamide moiety
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.88 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265559 | — | — | 1 | 7.66 |
| CHEMBL49354 | — | — | 2 | 7.52 |
| CHEMBL295806 | — | — | 2 | 7.52 |
| CHEMBL48636 | — | — | 1 | 7.40 |
| CHEMBL48988 | — | — | 1 | 6.66 |
| CHEMBL300422 | — | — | 1 | 6.58 |
| CHEMBL48665 | — | — | 1 | 5.85 |
| CHEMBL48546 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265559 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL295806 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL49354 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL48636 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL49354 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL295806 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL48988 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL300422 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL48665 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL48546 | — | IC50 | = | 2200.0 | nM | 5.66 |