Assay Detail
Binding
CHEMBL759075
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Displacement of [3H]PDBu from protein kinase C delta C1b domain mutant (L20G)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structural basis of binding of high-affinity ligands to protein kinase C: prediction of the binding modes through a new molecular dynamics method and evaluation by site-directed mutagenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.07 | 8.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46094 | — | — | 1 | 8.97 |
| CHEMBL27768 | — | — | 1 | 8.18 |
| CHEMBL49689 | THYMELEATOXIN | — | 1 | 7.95 |
| CHEMBL27266 | INDOLACTUM | — | 1 | 7.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46094 | — | Ki | = | 1.08 | nM | 8.97 |
| CHEMBL27768 | — | Ki | = | 6.59 | nM | 8.18 |
| CHEMBL49689 | THYMELEATOXIN | Ki | = | 11.27 | nM | 7.95 |
| CHEMBL27266 | INDOLACTUM | Ki | = | 66.2 | nM | 7.18 |