Assay Detail
Binding
CHEMBL759081
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Displacement of [3H]PDBu from protein kinase C delta C1b domain (Wild type)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structural basis of binding of high-affinity ligands to protein kinase C: prediction of the binding modes through a new molecular dynamics method and evaluation by site-directed mutagenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.35 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46094 | — | — | 1 | 9.89 |
| CHEMBL27768 | — | — | 1 | 9.46 |
| CHEMBL27266 | INDOLACTUM | — | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46094 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL27768 | — | Ki | = | 0.351 | nM | 9.46 |
| CHEMBL27266 | INDOLACTUM | Ki | = | 2.01 | nM | 8.70 |