Assay Detail
Functional
CHEMBL759088
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required for antiviral activity in PBMC (human peripheral blood mononuclear cells) infected with HIV-1 strain LAV
43
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-activity relationships of beta-D-(2S,5R)- and alpha-D-(2S,5S)-1,3-oxathiolanyl nucleosides as potential anti-HIV agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 43 | 6.09 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL490033 | — | — | 1 | 8.89 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 2 | 8.74 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.40 |
| CHEMBL89357 | — | — | 1 | 7.92 |
| CHEMBL300793 | — | — | 1 | 7.80 |
| CHEMBL417332 | — | — | 1 | 7.52 |
| CHEMBL89305 | — | — | 1 | 7.30 |
| CHEMBL313807 | — | — | 1 | 6.76 |
| CHEMBL89371 | — | — | 1 | 6.55 |
| CHEMBL89764 | — | — | 1 | 6.55 |
| CHEMBL330087 | — | — | 1 | 6.55 |
| CHEMBL89554 | — | — | 1 | 6.42 |
| CHEMBL89555 | — | — | 1 | 6.32 |
| CHEMBL313461 | — | — | 1 | 6.28 |
| CHEMBL421176 | — | — | 1 | 6.08 |
| CHEMBL88429 | — | — | 1 | 5.96 |
| CHEMBL328799 | — | — | 1 | 5.72 |
| CHEMBL329633 | — | — | 1 | 5.64 |
| CHEMBL86550 | — | — | 1 | 5.57 |
| CHEMBL89759 | — | — | 1 | 5.55 |
| CHEMBL328222 | — | — | 1 | 5.25 |
| CHEMBL88360 | — | — | 1 | 5.20 |
| CHEMBL445629 | — | — | 1 | 5.12 |
| CHEMBL89447 | — | — | 1 | 4.94 |
| CHEMBL314354 | — | — | 1 | 4.93 |
| CHEMBL88916 | — | — | 1 | 4.92 |
| CHEMBL330542 | — | — | 1 | 4.53 |
| CHEMBL90503 | — | — | 1 | 4.52 |
| CHEMBL88681 | — | — | 1 | 4.21 |
| CHEMBL89911 | — | — | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL490033 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL89357 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL300793 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL417332 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL89305 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL313807 | — | EC50 | = | 172.0 | nM | 6.76 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL89371 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL89764 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL330087 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL89554 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL89555 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL313461 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL421176 | — | EC50 | = | 830.0 | nM | 6.08 |
| CHEMBL88429 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL328799 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL329633 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL86550 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL89759 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL328222 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL88360 | — | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL445629 | — | EC50 | = | 7620.0 | nM | 5.12 |
| CHEMBL89447 | — | EC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL314354 | — | EC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL88916 | — | EC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL330542 | — | EC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL90503 | — | EC50 | = | 30400.0 | nM | 4.52 |
| CHEMBL88681 | — | EC50 | = | 61900.0 | nM | 4.21 |
| CHEMBL89911 | — | EC50 | = | 77500.0 | nM | 4.11 |
| CHEMBL330345 | — | EC50 | = | 94700.0 | nM | 4.02 |
| CHEMBL89449 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL90446 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL89417 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL86601 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL330119 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL89365 | — | EC50 | = | 112100.0 | nM | - |
| CHEMBL89149 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL314404 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL327373 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL89172 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL313615 | — | EC50 | > | 100000.0 | nM | - |