Assay Detail
Binding
CHEMBL759152
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Inhibitory concentration against cGMP PDE II enzyme in guinea pig
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
cGMP-dependent 3',5'-cyclic phosphodiesterase (CHEMBL2652) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Cardiotonic agents. 7. Inhibition of separated forms of cyclic nucleotide phosphodiesterase from guinea pig cardiac muscle by 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and related compounds. Structure-activity relationships and correlation with in vivo positive inotropic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.25 | 4.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30402 | — | — | 1 | 4.47 |
| CHEMBL30623 | — | — | 1 | 4.41 |
| CHEMBL282765 | TETRAHYDROBENXIMIDAZOLE | — | 1 | 4.37 |
| CHEMBL30362 | — | — | 1 | 4.15 |
| CHEMBL448467 | — | — | 1 | 4.06 |
| CHEMBL30908 | — | — | 1 | 4.04 |
| CHEMBL31112 | — | — | 1 | - |
| CHEMBL31105 | — | — | 1 | - |
| CHEMBL30368 | — | — | 1 | - |
| CHEMBL30358 | — | — | 1 | - |
| CHEMBL58728 | — | — | 1 | - |
| CHEMBL30367 | — | — | 1 | - |
| CHEMBL286502 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30402 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL30623 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL282765 | TETRAHYDROBENXIMIDAZOLE | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL30362 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL448467 | — | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL30908 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL31112 | — | IC50 | = | 280000.0 | nM | - |
| CHEMBL31105 | — | IC50 | = | 170000.0 | nM | - |
| CHEMBL30368 | — | IC50 | = | 380000.0 | nM | - |
| CHEMBL30358 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL58728 | — | IC50 | = | 180000.0 | nM | - |
| CHEMBL30367 | — | IC50 | = | 340000.0 | nM | - |
| CHEMBL286502 | — | IC50 | = | 350000.0 | nM | - |