Assay Detail
Binding
CHEMBL759161
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Inhibitory concentration against cAMP PDE III enzyme in guinea pig
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Cardiotonic agents. 7. Inhibition of separated forms of cyclic nucleotide phosphodiesterase from guinea pig cardiac muscle by 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and related compounds. Structure-activity relationships and correlation with in vivo positive inotropic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.12 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440593 | CI-930 | — | 1 | 6.22 |
| CHEMBL189 | MILRINONE | 4.0 | 1 | 5.60 |
| CHEMBL287398 | — | — | 1 | 5.14 |
| CHEMBL12831 | IMAZODAN | 2.0 | 1 | 5.10 |
| CHEMBL31762 | — | — | 1 | 4.37 |
| CHEMBL12856 | INAMRINONE | 4.0 | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440593 | CI-930 | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL189 | MILRINONE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL287398 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL12831 | IMAZODAN | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL31762 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL12856 | INAMRINONE | IC50 | = | 50000.0 | nM | 4.30 |