Compound Detail
CHEMBL31762
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Basic Information
| ChEMBL ID | CHEMBL31762 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FJSIMGWFNGHVSV-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
254.3
MW (Da)
1.73
ALogP
4
HBA
1
HBD
59.3
PSA (Ų)
0.89
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 4.37
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphodiesterase 3 CHEMBL2094125 | IC50 | 4.37 | 4.37 | 43000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphodiesterase 3 | IC50 | = | 43000.0 | nM | 4.37 | Inhibitory concentration against cAMP PDE III enzyme in guinea pig | 2822926 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2822926 | 10.1021/jm00394a005 | Phosphodiesterase 1 | 6 |
| 2822926 | 10.1021/jm00394a005 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 6 |
| 2822926 | 10.1021/jm00394a005 | Phosphodiesterase 3 | 3 |
| 2822926 | 10.1021/jm00394a005 | Unchecked | 2 |
| 3656349 | 10.1021/jm00393a007 | Canis familiaris | 1 |
| 2864447 | 10.1021/jm00148a006 | Canis familiaris | 1 |
| 2822926 | 10.1021/jm00394a005 | Canis familiaris | 1 |
Data from ChEMBL 36 via Core Engine