Assay Detail
Binding
CHEMBL759168
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Inhibition of PDE 3 (phosphodiesterase III) from guinea pig ventricle
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Cyclic nucleotide phosphodiesterase inhibition by imidazopyridines: analogues of sulmazole and isomazole as inhibitors of the cGMP specific phosphodiesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.81 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38224 | INDOLIDAN | 2.0 | 1 | 7.10 |
| CHEMBL189 | MILRINONE | 4.0 | 1 | 6.52 |
| CHEMBL12831 | IMAZODAN | 2.0 | 1 | 5.22 |
| CHEMBL2110680 | ISOMAZOLE | 2.0 | 1 | 4.38 |
| CHEMBL286020 | SULMAZOLE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38224 | INDOLIDAN | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL189 | MILRINONE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL12831 | IMAZODAN | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL2110680 | ISOMAZOLE | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL286020 | SULMAZOLE | IC50 | = | 150000.0 | nM | - |