Compound Detail
CHEMBL38224
INDOLIDAN 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL38224 |
| Name | INDOLIDAN |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | LZCQFJKUAIWHRW-UHFFFAOYSA-N |
3
Targets
7
Activities
2
Assay Types
3
PK Parameters
15
Publications
3
Known Names
Molecular Properties
257.3
MW (Da)
1.53
ALogP
3
HBA
2
HBD
70.6
PSA (Ų)
0.80
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
IC50 5 meas. best 7.1
Ki 2 meas. best 8.27
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphodiesterase 4 CHEMBL2093863 | Ki | 8.27 | 8.27 | 5.4 | 1 |
| Phosphodiesterase 3 CHEMBL2094125 | IC50 | 7.1 | 6.4533 | 80.0 | 3 |
| Phosphodiesterase; PDE3 & PDE4 CHEMBL2095153 | Ki | 7.1 | 7.1 | 80.0 | 1 |
| Phosphodiesterase; PDE3 & PDE4 CHEMBL2095153 | IC50 | 6.89 | 6.89 | 130.0 | 1 |
| Phosphodiesterase 4 CHEMBL2093863 | IC50 | 6.82 | 6.82 | 150.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| F | 100.0 | % | Canis lupus familiaris |
| T1/2 | 8.0 | hr | Canis lupus familiaris |
| T1/2 | 14.0 | hr | Canis lupus familiaris |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphodiesterase 4 | Ki | = | 5.4 | nM | 8.27 | Displacement [3H]LY-186,126 from phosphodiesterase 4 of myocardial vesicles | 2738882 |
| Phosphodiesterase 3 | IC50 | = | 80.0 | nM | 7.1 | Inhibition of PDE 3 (phosphodiesterase III) from guinea pig ventricle | 8388468 |
| Phosphodiesterase 3 | IC50 | = | 80.0 | nM | 7.1 | Inhibition of human recombinant PDE3 expressed in Escherichia coli | 37077378 |
| Phosphodiesterase; PDE3 & PDE4 | Ki | = | 80.0 | nM | 7.1 | Inhibition of Sarcoplasmic Reticulum cAMP Phosphodiesterase from canine myocardi... | 3033241 |
| Phosphodiesterase; PDE3 & PDE4 | IC50 | = | 130.0 | nM | 6.89 | Inhibition of Sarcoplasmic Reticulum cAMP Phosphodiesterase from canine myocardi... | 3033241 |
| Phosphodiesterase 4 | IC50 | = | 150.0 | nM | 6.82 | Inhibition of sarcoplasmic reticulum Phosphodiesterase 4 | 2738882 |
| Phosphodiesterase 3 | IC50 | = | 7000.0 | nM | 5.16 | Inhibition of cardiac phosphodiesterase-3 isolated from canine heart. | 2153210 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 3761304 | 10.1021/jm00160a006 | Canis familiaris | 6 |
| 2153210 | 10.1021/jm00163a061 | Canis familiaris | 4 |
| 3033241 | 10.1021/jm00388a014 | Canis familiaris | 3 |
| 8388468 | 10.1021/jm00062a011 | Phosphodiesterase 3 | 3 |
| 3031290 | 10.1021/jm00387a007 | Canis familiaris | 3 |
| 3761304 | 10.1021/jm00160a006 | Felis catus | 3 |
| 2544724 | 10.1021/jm00127a015 | Canis familiaris | 3 |
| 3033241 | 10.1021/jm00388a014 | Phosphodiesterase; PDE3 & PDE4 | 2 |
| 2738882 | 10.1021/jm00127a014 | Phosphodiesterase 4 | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 1310113 | 10.1021/jm00079a022 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | 1 |
| 2738882 | 10.1021/jm00127a014 | Canis familiaris | 1 |
| 3761304 | 10.1021/jm00160a006 | ADMET | 1 |
| 2153210 | 10.1021/jm00163a061 | Phosphodiesterase 3 | 1 |
| 37077378 | 10.1021/acsmedchemlett.3c00092 | Phosphodiesterase 3 | 1 |
Data from ChEMBL 36 via Core Engine