Assay Detail
Binding
CHEMBL5256543
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PDE3 expressed in Escherichia coli
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Anagrelide: A Clinically Effective cAMP Phosphodiesterase 3A Inhibitor with Molecular Glue Properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.51 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69139 | LIXAZINONE | 2.0 | 1 | 8.00 |
| CHEMBL34431 | CILOSTAMIDE | 2.0 | 1 | 7.57 |
| CHEMBL760 | ANAGRELIDE | 4.0 | 1 | 7.52 |
| CHEMBL5283704 | — | — | 1 | 7.50 |
| CHEMBL66522 | — | — | 1 | 7.16 |
| CHEMBL38224 | INDOLIDAN | 2.0 | 1 | 7.10 |
| CHEMBL299631 | — | — | 1 | 7.05 |
| CHEMBL799 | CILOSTAZOL | 4.0 | 1 | 6.70 |
| CHEMBL189 | MILRINONE | 4.0 | 1 | 6.35 |
| CHEMBL313842 | ZARDAVERINE | 2.0 | 1 | 6.24 |
| CHEMBL320341 | QUAZINONE | 2.0 | 1 | 6.24 |
| CHEMBL5278813 | — | — | 1 | 6.22 |
| CHEMBL249856 | ENOXIMONE | 3.0 | 1 | 5.23 |
| CHEMBL12831 | IMAZODAN | 2.0 | 1 | 5.21 |
| CHEMBL17423 | VESNARINONE | 2.0 | 1 | 5.21 |
| CHEMBL12856 | INAMRINONE | 4.0 | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69139 | LIXAZINONE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL34431 | CILOSTAMIDE | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL760 | ANAGRELIDE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5283704 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL66522 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL38224 | INDOLIDAN | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL299631 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL799 | CILOSTAZOL | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL189 | MILRINONE | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL313842 | ZARDAVERINE | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL320341 | QUAZINONE | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL5278813 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL249856 | ENOXIMONE | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL12831 | IMAZODAN | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL17423 | VESNARINONE | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL12856 | INAMRINONE | IC50 | = | 16700.0 | nM | 4.78 |