Compound Detail
CHEMBL320341
QUAZINONE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL320341 |
| Name | QUAZINONE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | BHZFZYLBVSWUMT-ZCFIWIBFSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
8
Publications
7
Known Names
Molecular Properties
235.7
MW (Da)
1.66
ALogP
3
HBA
1
HBD
44.7
PSA (Ų)
0.74
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Activity Summary
IC50 2 meas. best 6.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphodiesterase 3 CHEMBL2094125 | IC50 | 6.62 | 6.43 | 240.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphodiesterase 3 | IC50 | = | 240.0 | nM | 6.62 | Inhibition of platelet cAMP phosphodiesterase | 2846839 |
| Phosphodiesterase 3 | IC50 | = | 580.0 | nM | 6.24 | Inhibition of human recombinant PDE3 expressed in Escherichia coli | 37077378 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2769678 | 10.1021/jm00129a005 | Canis familiaris | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 2846839 | 10.1021/jm00119a014 | Phosphodiesterase 3 | 1 |
| 3027335 | 10.1021/jm00385a001 | Phosphodiesterase; PDE3 & PDE4 | 1 |
| 3027335 | 10.1021/jm00385a001 | Beta-1 adrenergic receptor | 1 |
| 2153209 | 10.1021/jm00163a052 | Canis familiaris | 1 |
| 17417631 | 10.1038/nchembio873 | Unchecked | 1 |
| 37077378 | 10.1021/acsmedchemlett.3c00092 | Phosphodiesterase 3 | 1 |
Data from ChEMBL 36 via Core Engine