Assay Detail
Binding
CHEMBL821993
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Inhibition of platelet cAMP phosphodiesterase
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Inhibitors of cyclic AMP phosphodiesterase. 3. Synthesis and biological evaluation of pyrido and imidazolyl analogues of 1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazoline.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.01 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69139 | LIXAZINONE | 2.0 | 1 | 8.00 |
| CHEMBL66522 | — | — | 1 | 7.16 |
| CHEMBL760 | ANAGRELIDE | 4.0 | 1 | 7.10 |
| CHEMBL440593 | CI-930 | — | 1 | 6.82 |
| CHEMBL31580 | — | — | 1 | 6.82 |
| CHEMBL320341 | QUAZINONE | 2.0 | 1 | 6.62 |
| CHEMBL67513 | — | — | 1 | 6.54 |
| CHEMBL66978 | — | — | 1 | 6.28 |
| CHEMBL66447 | — | — | 1 | 6.25 |
| CHEMBL66153 | — | — | 1 | 6.22 |
| CHEMBL66061 | — | — | 1 | 6.16 |
| CHEMBL189 | MILRINONE | 4.0 | 1 | 6.07 |
| CHEMBL65882 | — | — | 1 | 5.82 |
| CHEMBL66212 | — | — | 1 | 5.82 |
| CHEMBL70033 | — | — | 1 | 5.70 |
| CHEMBL69286 | — | — | 1 | 5.48 |
| CHEMBL65700 | — | — | 1 | 5.06 |
| CHEMBL302575 | — | — | 1 | 4.75 |
| CHEMBL66935 | — | — | 1 | 4.58 |
| CHEMBL69940 | — | — | 1 | 4.52 |
| CHEMBL428866 | — | — | 1 | 4.43 |
| CHEMBL307996 | — | — | 1 | - |
| CHEMBL58355 | PIROXIMONE | 2.0 | 1 | - |
| CHEMBL68833 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69139 | LIXAZINONE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL66522 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL760 | ANAGRELIDE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL440593 | CI-930 | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL31580 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL320341 | QUAZINONE | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL67513 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL66978 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL66447 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL66153 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL66061 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL189 | MILRINONE | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL65882 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL66212 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL70033 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL69286 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL65700 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL302575 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL66935 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL69940 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL428866 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL307996 | — | IC50 | = | 330000.0 | nM | - |
| CHEMBL58355 | PIROXIMONE | IC50 | > | 100000.0 | nM | - |
| CHEMBL68833 | — | IC50 | = | 250000.0 | nM | - |