Compound Detail
CHEMBL66153
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL66153 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LOEONLVPVKZMHH-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
253.3
MW (Da)
0.81
ALogP
5
HBA
1
HBD
62.5
PSA (Ų)
0.82
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphodiesterase 3 CHEMBL2094125 | IC50 | 6.22 | 6.22 | 600.0 | 1 |
| Homo sapiens CHEMBL372 | IC50 | 5.22 | 5.22 | 6000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphodiesterase 3 | IC50 | = | 600.0 | nM | 6.22 | Inhibition of platelet cAMP phosphodiesterase | 2846839 |
| Homo sapiens | IC50 | = | 6000.0 | nM | 5.22 | Inhibition of ADP induced platelet aggregation | 2846839 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2846839 | 10.1021/jm00119a014 | Canis familiaris | 4 |
| 2846839 | 10.1021/jm00119a014 | Phosphodiesterase 3 | 1 |
| 2846839 | 10.1021/jm00119a014 | Homo sapiens | 1 |
Data from ChEMBL 36 via Core Engine