Compound Detail
CHEMBL58355
PIROXIMONE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL58355 |
| Name | PIROXIMONE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | OQGWJZOWLHWFME-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
18
Publications
4
Known Names
Molecular Properties
217.2
MW (Da)
0.89
ALogP
3
HBA
2
HBD
78.6
PSA (Ų)
0.75
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
IC50 4 meas. best 5.07
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphodiesterase 3 CHEMBL2094125 | IC50 | 5.07 | 5.07 | 8600.0 | 2 |
| Homo sapiens CHEMBL372 | IC50 | 4.82 | 4.52 | 15000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphodiesterase 3 | IC50 | = | 8600.0 | nM | 5.07 | Inhibition of low Km cyclic AMP phosphodiesterase PDE III of canine ventricle | 2985781 |
| Phosphodiesterase 3 | IC50 | = | 8600.0 | nM | 5.07 | Inhibition of cAMP PDE III enzyme | 2822927 |
| Homo sapiens | IC50 | = | 15000.0 | nM | 4.82 | In vitro inhibition of collagen stimulated platelet aggregation in human thrombo... | 2536438 |
| Homo sapiens | IC50 | = | 60000.0 | nM | 4.22 | In vitro inhibition of ADP stimulated platelet aggregation in human thrombocyte ... | 2536438 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15646539 | 10.1016/s0399-8320(04)95062-2 | Unchecked | 11 |
| 15646539 | 10.1016/s0399-8320(04)95062-2 | NON-PROTEIN TARGET | 8 |
| 2536438 | 10.1021/jm00122a011 | Canis familiaris | 5 |
| 3701794 | 10.1021/jm00155a043 | Canis familiaris | 3 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 2846839 | 10.1021/jm00119a014 | Phosphodiesterase 3 | 2 |
| 2846839 | 10.1021/jm00119a014 | Canis familiaris | 2 |
| 2536438 | 10.1021/jm00122a011 | Homo sapiens | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 3027335 | 10.1021/jm00385a001 | Beta-1 adrenergic receptor | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| 20022146 | 10.1016/j.ejmech.2009.11.034 | Homo sapiens | 1 |
| 3027335 | 10.1021/jm00385a001 | Phosphodiesterase; PDE3 & PDE4 | 1 |
| 2822927 | 10.1021/jm00394a006 | Phosphodiesterase 3 | 1 |
| 2822927 | 10.1021/jm00394a006 | Canis familiaris | 1 |
| 2985781 | 10.1021/jm50001a001 | Phosphodiesterase 3 | 1 |
Data from ChEMBL 36 via Core Engine