Assay Detail
Functional
CHEMBL698310
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of ADP stimulated platelet aggregation in human thrombocyte enriched plasma
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Cardiotonic agents. 9. Synthesis and biological evaluation of a series of (E)-4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]ethenyl]-3 (2H)-pyridazinones: a novel class of compounds with positive inotropic, antithrombotic, and vasodilatory activities for the treatment of congestive heart failure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.17 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL544813 | — | — | 1 | 6.52 |
| CHEMBL282765 | TETRAHYDROBENXIMIDAZOLE | — | 1 | 5.40 |
| CHEMBL440593 | CI-930 | — | 1 | 5.40 |
| CHEMBL115915 | — | — | 1 | 5.40 |
| CHEMBL332341 | — | — | 1 | 5.30 |
| CHEMBL119237 | — | — | 1 | 5.22 |
| CHEMBL333083 | — | — | 1 | 5.22 |
| CHEMBL189 | MILRINONE | 4.0 | 1 | 5.00 |
| CHEMBL12831 | IMAZODAN | 2.0 | 1 | 4.70 |
| CHEMBL117783 | — | — | 1 | 4.52 |
| CHEMBL58355 | PIROXIMONE | 2.0 | 1 | 4.22 |
| CHEMBL249856 | ENOXIMONE | 3.0 | 1 | - |
| CHEMBL12856 | INAMRINONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL544813 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL282765 | TETRAHYDROBENXIMIDAZOLE | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL440593 | CI-930 | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL115915 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL332341 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL119237 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL333083 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL189 | MILRINONE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL12831 | IMAZODAN | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL117783 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL58355 | PIROXIMONE | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL249856 | ENOXIMONE | IC50 | = | 120000.0 | nM | - |
| CHEMBL12856 | INAMRINONE | IC50 | = | 250000.0 | nM | - |