Compound Detail
CHEMBL249856
ENOXIMONE 🧪 Phase III
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🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL249856 |
| Name | ENOXIMONE |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | ZJKNESGOIKRXQY-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
5
Targets
13
Activities
2
Assay Types
7
PK Parameters
20
Publications
5
Known Names
3
Indications
1
Mechanisms
Molecular Properties
248.3
MW (Da)
1.96
ALogP
3
HBA
2
HBD
65.7
PSA (Ų)
0.64
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Phosphodiesterase 3 inhibitor | INHIBITOR | Phosphodiesterase 3 | ✓ | ✓ |
Indications
Cardiovascular Diseases Coronary Disease Heart Failure
ATC Classification
C01CE03
enoximone
Level 1: CARDIOVASCULAR SYSTEM
Level 2: CARDIAC THERAPY
Activity Summary
IC50 11 meas. best 5.57
EC50 2 meas. best 4.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphodiesterase; PDE3 & PDE4 CHEMBL2095153 | IC50 | 5.57 | 5.57 | 2700.0 | 1 |
| Phosphodiesterase 4 CHEMBL2093863 | IC50 | 5.54 | 5.42 | 2900.0 | 2 |
| Phosphodiesterase 3 CHEMBL2094125 | IC50 | 5.42 | 5.04 | 3800.0 | 5 |
| Homo sapiens CHEMBL372 | IC50 | 4.82 | 4.82 | 15000.0 | 1 |
| Felis catus CHEMBL612670 | EC50 | 4.05 | 4.05 | 90000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 29.0 | mL.min-1.kg-1 | Homo sapiens |
| CL | 29.0 | mL.min-1.kg-1 | Homo sapiens |
| F | 79.0 | % | Homo sapiens |
| F | 53.0 | % | Homo sapiens |
| Fu | 0.3 | - | Homo sapiens |
| MRT | 1.0 | hr | Homo sapiens |
| T1/2 | 1.0 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine