Assay Detail
Binding
CHEMBL762673
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of fraction III of guinea pig phosphodiesterase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Cardiotonic agents. 1. 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3 (2H)-pyridazinones: novel positive inotropic agents for the treatment of congestive heart failure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.21 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440593 | CI-930 | — | 1 | 6.22 |
| CHEMBL189 | MILRINONE | 4.0 | 1 | 5.60 |
| CHEMBL12831 | IMAZODAN | 2.0 | 1 | 5.10 |
| CHEMBL249856 | ENOXIMONE | 3.0 | 1 | 4.85 |
| CHEMBL12856 | INAMRINONE | 4.0 | 1 | 4.30 |
| CHEMBL286020 | SULMAZOLE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440593 | CI-930 | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL189 | MILRINONE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL12831 | IMAZODAN | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL249856 | ENOXIMONE | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL12856 | INAMRINONE | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL286020 | SULMAZOLE | IC50 | = | 500000.0 | nM | - |