Assay Detail
Binding
CHEMBL759160
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Inhibition of cAMP PDE III enzyme
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Cardiotonic agents. 8. Selective inhibitors of adenosine 3',5'-cyclic phosphate phosphodiesterase III. Elaboration of a five-point model for positive inotropic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.34 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL299631 | — | — | 1 | 6.92 |
| CHEMBL440593 | CI-930 | — | 1 | 6.22 |
| CHEMBL58005 | — | — | 1 | 5.92 |
| CHEMBL58460 | — | — | 1 | 5.80 |
| CHEMBL300175 | — | — | 1 | 5.75 |
| CHEMBL61692 | — | — | 1 | 5.72 |
| CHEMBL189 | MILRINONE | 4.0 | 1 | 5.60 |
| CHEMBL287398 | — | — | 1 | 5.14 |
| CHEMBL12831 | IMAZODAN | 2.0 | 1 | 5.10 |
| CHEMBL58355 | PIROXIMONE | 2.0 | 1 | 5.07 |
| CHEMBL58728 | — | — | 1 | 4.92 |
| CHEMBL249856 | ENOXIMONE | 3.0 | 1 | 4.85 |
| CHEMBL30367 | — | — | 1 | 4.40 |
| CHEMBL12856 | INAMRINONE | 4.0 | 1 | 4.34 |
| CHEMBL31105 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL299631 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL440593 | CI-930 | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL58005 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL58460 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL300175 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL61692 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL189 | MILRINONE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL287398 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL12831 | IMAZODAN | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL58355 | PIROXIMONE | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL58728 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL249856 | ENOXIMONE | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL30367 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL12856 | INAMRINONE | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL31105 | — | IC50 | = | 50000.0 | nM | 4.30 |