Assay Detail
Functional
CHEMBL876950
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The inotropic activity was assayed in vitro in cat papillary muscle
25
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Felis catus |
| Tissue | Muscle tissue |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Chemistry and positive inotropic effect of pelrinone and related derivatives. A novel class of 2-methylpyrimidones as inotropic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 5.01 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL354520 | — | — | 1 | 5.92 |
| CHEMBL166386 | — | — | 1 | 5.72 |
| CHEMBL352493 | — | — | 1 | 5.58 |
| CHEMBL168623 | — | — | 2 | 5.55 |
| CHEMBL165705 | — | — | 1 | 5.41 |
| CHEMBL167726 | — | — | 1 | 5.36 |
| CHEMBL354138 | — | — | 1 | 5.28 |
| CHEMBL355351 | — | — | 1 | 5.26 |
| CHEMBL17125 | PELRINONE | 2.0 | 1 | 5.23 |
| CHEMBL168456 | — | — | 1 | 5.21 |
| CHEMBL355520 | — | — | 1 | 5.19 |
| CHEMBL12831 | IMAZODAN | 2.0 | 1 | 5.16 |
| CHEMBL189 | MILRINONE | 4.0 | 1 | 5.11 |
| CHEMBL169113 | — | — | 1 | 5.00 |
| CHEMBL168342 | — | — | 1 | 4.85 |
| CHEMBL167101 | — | — | 1 | 4.70 |
| CHEMBL166414 | — | — | 1 | 4.60 |
| CHEMBL443039 | — | — | 1 | 4.48 |
| CHEMBL355293 | — | — | 1 | 4.43 |
| CHEMBL262775 | — | — | 1 | 4.37 |
| CHEMBL166525 | — | — | 1 | 4.26 |
| CHEMBL422375 | — | — | 1 | 4.14 |
| CHEMBL249856 | ENOXIMONE | 3.0 | 1 | 4.05 |
| CHEMBL169024 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL354520 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL166386 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL352493 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL168623 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL165705 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL168623 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL167726 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL354138 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL355351 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL17125 | PELRINONE | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL168456 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL355520 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL12831 | IMAZODAN | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL189 | MILRINONE | EC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL169113 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL168342 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL167101 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL166414 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL443039 | — | EC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL355293 | — | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL262775 | — | EC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL166525 | — | EC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL422375 | — | EC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL249856 | ENOXIMONE | EC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL169024 | — | EC50 | = | 230000.0 | nM | - |