Phosphodiesterase; PDE3 & PDE4 · SELECTIVITY GROUP · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P27815. Use UniProt P27815 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P27815 as the stable identity anchor, then attach disease evidence before program review.
3',5'-cyclic-AMP phosphodiesterase 4A
Review this target as Phosphodiesterase; PDE3 & PDE4, mapped to UniProt P27815. ChEMBL maps the protein component as 3',5'-cyclic-AMP phosphodiesterase 4A. Sequence length is 886 aa.
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This review treats Phosphodiesterase; PDE3 & PDE4 as ChEMBL target CHEMBL2095153, mapped to UniProt P27815. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Phosphodiesterase; PDE3 & PDE4 |
| Target Type | SELECTIVITY GROUP |
| Organism | Homo sapiens |
| UniProt | P27815 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 3',5'-cyclic-AMP phosphodiesterase 4A |
| UniProt Accession | P27815 |
| Component Type | Protein |
| Sequence Length | 886 aa |
3',5'-cyclic-AMP phosphodiesterase 4A
Review this target as Phosphodiesterase; PDE3 & PDE4, mapped to UniProt P27815. ChEMBL maps the protein component as 3',5'-cyclic-AMP phosphodiesterase 4A. Sequence length is 886 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL38017 | 7.89 | IC50 | 13.0 | Preclinical |
| CHEMBL46127 | 7.44 | IC50 | 36.0 | Preclinical |
| CHEMBL2114400 | 7.14 | IC50 | 73.0 | Preclinical |
| CHEMBL38224 | 7.1 | Ki | 80.0 | Clinical |
| CHEMBL280360 | 6.92 | IC50 | 120.0 | Preclinical |
| CHEMBL440593 | 6.92 | IC50 | 120.0 | Preclinical |
| CHEMBL38224 | 6.89 | IC50 | 130.0 | Clinical |
| CHEMBL19984 | 6.8 | IC50 | 160.0 | Preclinical |
| CHEMBL416178 | 6.8 | IC50 | 160.0 | Preclinical |
| CHEMBL417529 | 6.77 | IC50 | 170.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 20 | 24 | 5.9 |
| assay format | 3 | 0 | — |
| tissue-based format | 2 | 10 | 6.5 |
| organism-based format | 1 | 0 | — |