Compound Detail
CHEMBL5283704
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Basic Information
| ChEMBL ID | CHEMBL5283704 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KAXTUTDKZVOONF-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
272.1
MW (Da)
1.24
ALogP
4
HBA
2
HBD
64.9
PSA (Ų)
0.75
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.32
IC50 1 meas. best 7.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphodiesterase 3 CHEMBL2094125 | IC50 | 7.5 | 7.5 | 32.0 | 1 |
| Unchecked CHEMBL612545 | EC50 | 7.32 | 7.32 | 48.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphodiesterase 3 | IC50 | = | 32.0 | nM | 7.5 | Inhibition of human recombinant PDE3 expressed in Escherichia coli | 37077378 |
| Unchecked | EC50 | = | 48.0 | nM | 7.32 | Antiplatelet activity against ADP-induced Wistar rat platelet aggregation assess... | 37077378 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37077378 | 10.1021/acsmedchemlett.3c00092 | Phosphodiesterase 3 | 1 |
| 37077378 | 10.1021/acsmedchemlett.3c00092 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine