Assay Detail
Binding
CHEMBL762140
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Inhibition of sarcoplasmic reticulum Phosphodiesterase 4
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis of a tritium-labeled indolidan analogue and its use as a radioligand for phosphodiesterase-inhibitor cardiotonic binding sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.62 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34945 | — | — | 1 | 6.92 |
| CHEMBL38224 | INDOLIDAN | 2.0 | 1 | 6.82 |
| CHEMBL417501 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34945 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL38224 | INDOLIDAN | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL417501 | — | IC50 | = | 760.0 | nM | 6.12 |