Assay Detail
Binding
CHEMBL762145
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement [3H]LY-186,126 from phosphodiesterase 4 of myocardial vesicles
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Tissue | Myocardium |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis of a tritium-labeled indolidan analogue and its use as a radioligand for phosphodiesterase-inhibitor cardiotonic binding sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.29 | 9.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38017 | — | — | 1 | 9.27 |
| CHEMBL38224 | INDOLIDAN | 2.0 | 1 | 8.27 |
| CHEMBL34945 | — | — | 1 | 7.40 |
| CHEMBL37981 | — | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38017 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL38224 | INDOLIDAN | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL34945 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL37981 | — | Ki | = | 61400.0 | nM | 4.21 |