Assay Detail
Functional
CHEMBL759180
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Agonists activity was evaluated by release of [Ca2+] release of HEK 293 cells stably transfected with rat-brain P2Y purinoceptor 1 (P2Y1-R)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Adenosine 5'-O-(1-boranotriphosphate) derivatives as novel P2Y(1) receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.63 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2021421 | — | — | 1 | 9.00 |
| CHEMBL2373179 | — | — | 1 | 8.70 |
| CHEMBL2364735 | — | — | 1 | 8.70 |
| CHEMBL601711 | — | — | 1 | 8.59 |
| CHEMBL1256935 | — | — | 1 | 8.44 |
| CHEMBL2364736 | — | — | 1 | 8.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2021421 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2373179 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2364735 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL601711 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL1256935 | — | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL2364736 | — | EC50 | = | 4.5 | nM | 8.35 |