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Compound Detail

CHEMBL2373179

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[BH3-]P(=O)(OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)OP(=O)([O-])OP(=O)([O-])[O-].[Na+].[Na+].[Na+].[Na+]

Basic Information

ChEMBL ID CHEMBL2373179
Phase Preclinical
Structure Type MOL
InChI Key ZWRIDLGVBOCDKE-QOEFZSBYSA-K
Parent Compound CHEMBL2448345
Active Moiety CHEMBL2448345
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

503.0
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C10H15BN5Na4O12P3
MW 592.95

Activity Summary

EC50 1 meas. best 8.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
P2Y purinoceptor 1
CHEMBL2497
EC50 8.7 8.7 2.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
12431066 10.1021/jm020251d Bos taurus 2
12431066 10.1021/jm020251d P2Y purinoceptor 1 1

Data from ChEMBL 36 via Core Engine