Assay Detail
Binding
CHEMBL759226
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Inhibition of [3H]- ]DAMGO binding to mu receptor from rat brain membrane
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Conformationally restricted deltorphin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.80 | 7.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63407 | — | — | 1 | 7.98 |
| CHEMBL132164 | — | — | 1 | 7.76 |
| CHEMBL436590 | — | — | 1 | 6.93 |
| CHEMBL20775 | DELTORPHIN A | — | 2 | 6.84 |
| CHEMBL129815 | — | — | 1 | 6.47 |
| CHEMBL338466 | — | — | 1 | 6.05 |
| CHEMBL338985 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63407 | — | Ki | = | 10.4 | nM | 7.98 |
| CHEMBL132164 | — | Ki | = | 17.5 | nM | 7.76 |
| CHEMBL436590 | — | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL20775 | DELTORPHIN A | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL129815 | — | Ki | = | 338.0 | nM | 6.47 |
| CHEMBL20775 | DELTORPHIN A | Ki | = | 415.0 | nM | 6.38 |
| CHEMBL338466 | — | Ki | = | 891.0 | nM | 6.05 |
| CHEMBL338985 | — | Ki | = | 955.0 | nM | 6.02 |