Assay Detail
Binding
CHEMBL759233
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Opioid receptor mu 1 binding affinity by displacement of radioligand [3H][DAla,MePhe,Gly-ol]enkephalin (DAGO) from rat brain membrane synaptosomes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.04 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278789 | DERMORPHIN | — | 1 | 9.55 |
| CHEMBL1790778 | — | — | 1 | 9.54 |
| CHEMBL2369626 | — | — | 1 | 9.34 |
| CHEMBL317956 | DELTORPHIN C | — | 1 | 6.83 |
| CHEMBL2370328 | — | — | 1 | 6.24 |
| CHEMBL1790779 | — | — | 1 | 6.20 |
| CHEMBL2370331 | — | — | 1 | 5.82 |
| CHEMBL2370329 | — | — | 1 | 5.77 |
| CHEMBL2370332 | — | — | 1 | 5.70 |
| CHEMBL2370333 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278789 | DERMORPHIN | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL1790778 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL2369626 | — | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL317956 | DELTORPHIN C | Ki | = | 147.0 | nM | 6.83 |
| CHEMBL2370328 | — | Ki | = | 578.9 | nM | 6.24 |
| CHEMBL1790779 | — | Ki | = | 634.9 | nM | 6.20 |
| CHEMBL2370331 | — | Ki | = | 1520.0 | nM | 5.82 |
| CHEMBL2370329 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL2370332 | — | Ki | = | 1993.0 | nM | 5.70 |
| CHEMBL2370333 | — | Ki | = | 4400.0 | nM | 5.36 |