Assay Detail
Binding
CHEMBL759235
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Inhibition of [3H]DAGO binding to rat brain membrane Opioid receptor mu 1
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Development of conformationally constrained linear peptides exhibiting a high affinity and pronounced selectivity for delta opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.74 | 7.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55734 | — | — | 1 | 7.63 |
| CHEMBL13786 | — | — | 1 | 7.56 |
| CHEMBL124283 | — | — | 1 | 7.51 |
| CHEMBL57776 | — | — | 1 | 7.38 |
| CHEMBL55498 | — | — | 1 | 7.19 |
| CHEMBL299029 | — | — | 1 | 6.73 |
| CHEMBL298972 | — | — | 1 | 6.43 |
| CHEMBL56933 | — | — | 1 | 6.32 |
| CHEMBL31421 | — | — | 1 | 6.06 |
| CHEMBL301702 | — | — | 1 | 6.00 |
| CHEMBL56394 | — | — | 1 | 5.35 |
| CHEMBL299497 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55734 | — | Ki | = | 23.3 | nM | 7.63 |
| CHEMBL13786 | — | Ki | = | 27.5 | nM | 7.56 |
| CHEMBL124283 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL57776 | — | Ki | = | 42.1 | nM | 7.38 |
| CHEMBL55498 | — | Ki | = | 64.6 | nM | 7.19 |
| CHEMBL299029 | — | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL298972 | — | Ki | = | 374.0 | nM | 6.43 |
| CHEMBL56933 | — | Ki | = | 475.0 | nM | 6.32 |
| CHEMBL31421 | — | Ki | = | 873.0 | nM | 6.06 |
| CHEMBL301702 | — | Ki | = | 993.0 | nM | 6.00 |
| CHEMBL56394 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL299497 | — | Ki | > | 100000.0 | nM | - |