Assay Detail
Functional
CHEMBL759333
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Compound was tested for its agonist activity against murine Peroxisome proliferator activated receptor alpha-Gal4 chimeric receptor transfected CV-1 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL2128) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.39 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278590 | GSK-9578 | — | 1 | 8.30 |
| CHEMBL124842 | — | — | 1 | 8.00 |
| CHEMBL340011 | — | — | 1 | 7.48 |
| CHEMBL125230 | — | — | 1 | 7.28 |
| CHEMBL124079 | — | — | 1 | 6.92 |
| CHEMBL981 | FENOFIBRIC ACID | 4.0 | 1 | 4.75 |
| CHEMBL683 | CLOFIBRIC ACID | 2.0 | 1 | 4.30 |
| CHEMBL264374 | BEZAFIBRATE | 3.0 | 1 | 4.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278590 | GSK-9578 | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL124842 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL340011 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL125230 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL124079 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL981 | FENOFIBRIC ACID | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL683 | CLOFIBRIC ACID | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL264374 | BEZAFIBRATE | EC50 | = | 90000.0 | nM | 4.05 |