Assay Detail
Binding
CHEMBL759409
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of bovine phenylethylamine N-methyl-transferase (PNMT) using radiochemical assay.
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Phenylethanolamine N-methyltransferase (CHEMBL2331) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Inhibition of phenylethanolamine N-methyltransferase (PNMT) by aromatic hydroxy-substituted 1,2,3,4,-tetrahydroisoquinolines: further studies on the hydrophilic pocket of the aromatic ring binding region of the active site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 5.17 | 6.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26717 | — | — | 1 | 6.26 |
| CHEMBL27730 | — | — | 1 | 5.58 |
| CHEMBL71354 | — | — | 1 | 5.42 |
| CHEMBL11862 | — | — | 1 | 5.24 |
| CHEMBL310736 | — | — | 1 | 5.11 |
| CHEMBL14346 | 1,2,3,4-TETRAHYDROISOQUINOLINE | — | 1 | 4.99 |
| CHEMBL26640 | — | — | 1 | 4.70 |
| CHEMBL308021 | — | — | 1 | 4.05 |
| CHEMBL70415 | — | — | 1 | - |
| CHEMBL306199 | — | — | 1 | - |
| CHEMBL309111 | — | — | 1 | - |
| CHEMBL69312 | — | — | 1 | - |
| CHEMBL61749 | — | — | 1 | - |
| CHEMBL61595 | — | — | 1 | - |
| CHEMBL71308 | — | — | 1 | - |
| CHEMBL302963 | — | — | 1 | - |
| CHEMBL68977 | — | — | 1 | - |
| CHEMBL299436 | — | — | 1 | - |
| CHEMBL71563 | — | — | 1 | - |
| CHEMBL49263 | — | — | 1 | - |
| CHEMBL61712 | — | — | 1 | - |
| CHEMBL292281 | — | — | 1 | - |
| CHEMBL291584 | — | — | 1 | - |
| CHEMBL70546 | — | — | 1 | - |
| CHEMBL303839 | — | — | 1 | - |
| CHEMBL70397 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26717 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL27730 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL71354 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL11862 | — | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL310736 | — | Ki | = | 7800.0 | nM | 5.11 |
| CHEMBL14346 | 1,2,3,4-TETRAHYDROISOQUINOLINE | Ki | = | 10300.0 | nM | 4.99 |
| CHEMBL26640 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL308021 | — | Ki | = | 90000.0 | nM | 4.05 |
| CHEMBL70415 | — | Ki | = | 1100000.0 | nM | - |
| CHEMBL306199 | — | Ki | = | 735000.0 | nM | - |
| CHEMBL309111 | — | Ki | > | 4000000.0 | nM | - |
| CHEMBL69312 | — | Ki | = | 1082000.0 | nM | - |
| CHEMBL61749 | — | Ki | = | 304000.0 | nM | - |
| CHEMBL61595 | — | Ki | = | 487000.0 | nM | - |
| CHEMBL71308 | — | Ki | = | 1259000.0 | nM | - |
| CHEMBL302963 | — | Ki | > | 2000000.0 | nM | - |
| CHEMBL68977 | — | Ki | = | 169000.0 | nM | - |
| CHEMBL299436 | — | Ki | = | 258000.0 | nM | - |
| CHEMBL71563 | — | Ki | = | 108000.0 | nM | - |
| CHEMBL49263 | — | Ki | = | 479000.0 | nM | - |
| CHEMBL61712 | — | Ki | > | 10000000.0 | nM | - |
| CHEMBL292281 | — | Ki | > | 3000000.0 | nM | - |
| CHEMBL291584 | — | Ki | = | 1114000.0 | nM | - |
| CHEMBL70546 | — | Ki | = | 550000.0 | nM | - |
| CHEMBL303839 | — | Ki | > | 2000000.0 | nM | - |
| CHEMBL70397 | — | Ki | > | 2000000.0 | nM | - |