Assay Detail
Functional
CHEMBL759436
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In vitro inhibition of lymphocyte activated CD2 antigens induced by monoclonal antibody
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A new rational hypothesis for the pharmacophore of the active metabolite of leflunomide, a potent immunosuppressive drug.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.73 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL304452 | — | — | 1 | 5.54 |
| CHEMBL64092 | — | — | 1 | 5.52 |
| CHEMBL64492 | — | — | 1 | 4.86 |
| CHEMBL62289 | — | — | 1 | 4.82 |
| CHEMBL973 | TERIFLUNOMIDE | 4.0 | 1 | 4.29 |
| CHEMBL292494 | — | — | 1 | 4.04 |
| CHEMBL61468 | — | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL304452 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL64092 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL64492 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL62289 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL973 | TERIFLUNOMIDE | IC50 | = | 50900.0 | nM | 4.29 |
| CHEMBL292494 | — | IC50 | = | 90800.0 | nM | 4.04 |
| CHEMBL61468 | — | IC50 | = | 95400.0 | nM | 4.02 |