Assay Detail
Binding
CHEMBL759466
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Inhibition of [3H]1-[1-(2-thienyl) piperidine ([3H]TCP) binding to PCP receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 2C (CHEMBL401) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Phencyclidine-like effects of tetrahydroisoquinolines and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.16 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL442106 | — | — | 1 | 6.05 |
| CHEMBL21484 | — | — | 1 | 5.60 |
| CHEMBL21830 | — | — | 1 | 5.12 |
| CHEMBL21323 | — | — | 1 | 5.09 |
| CHEMBL418745 | — | — | 1 | 5.07 |
| CHEMBL281568 | — | — | 1 | 5.06 |
| CHEMBL283378 | — | — | 1 | 4.92 |
| CHEMBL22133 | — | — | 1 | 4.77 |
| CHEMBL283377 | — | — | 1 | 4.77 |
| CHEMBL21477 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL442106 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL21484 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL21830 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL21323 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL418745 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL281568 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL283378 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL22133 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL283377 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL21477 | — | IC50 | > | 30000.0 | nM | - |